Scientist, ADC Discovery Research (non-PHD)
Pfizer Inc.
Washington – Bothell, NY
Job posting number: #7274798 (Ref:pf-4918232)
Posted: August 22, 2024
Job Description
Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.
You will participate in pre-clinical drug discovery and development projects with a focus on antibody-drug conjugates (ADC) that target oncogenic pathways and processes. You will work as a member of the ADC Biology team, performing a range of in vitro pharmacology and pharmacodynamic assays to understand the structure-activity relationships (SAR) of novel ADC payloads. You will be a technical and scientific specialist in the conduct of SAR studies and will be responsible for experimental study planning, design, and execution. You will be responsible for data collection, appropriate documentation, and accurate reporting and presentation of study data for multidisciplinary teams. You will work collaboratively in matrixed and cross-functional teams to efficiently address project needs in a timely manner.
Key Responsibilities
- Apply cellular and molecular biology laboratory techniques to preclinical research projects in the area of cancer biology, with a focus on oncogenic tumor dependency
- Support drug linker discovery and PD marker activities through execution of molecular and cell-based methodologies, including cytotoxicity assays, reporter assays, AlphaLISA/ELISA, and WES.
- Investigate novel biological MOAs of ADC linker payloads through development, optimization, and execution of complex assays
- Independently design, execute and document key experiments to enable clear go/no-go decisions; present findings to large and small audiences
- Provide leadership within technical area of expertise; may train others
- Maintain rigorous records of experimental progress using electronic laboratory notebooks
Qualifications
Must-Have
- Bachelor's Degree and 6+ years of experience or Master's degree and 4+ years of experience
- Degree in Molecular and Cellular Biology, Biochemistry, or a related field
- Experience with tissue culture and diverse molecular biology techniques,
- Ability to adapt and adjust to a rapidly evolving environment
- Ability to use critical thinking to address challenges and overcome obstacles
- Strong written and verbal communication skills with the ability to communicate effectively to a wide range of audiences
Nice-to-Have
- Experience working in the industry environment
- Background in cancer drug discovery related to ADC biology
- Experience in protein degradation and proteostasis is strongly preferred
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
