Postdoctoral Fellow in Cancer Epigenetics

University of Michigan

Ann Arbor, MI

Job posting number: #7070436

Posted: September 30, 2020

Application Deadline: Open Until Filled

Job Description

Description:
Postdoctoral position in biomedical science is available in Prof. Tomasz Cierpicki and Prof. Russell Ryan laboratories, University of Michigan, Ann Arbor, to carry out cancer epigenetic projects focused on studying the effect of small molecules blocking new epigenetic targets and to pursue target validation studies using genetic approaches. The research will focus on evaluation of the activity and the mechanism of action of novel small molecules blocking epigenetic proteins in cancer as well as evaluation of epigenetic and functional effects of perturbing chromatin regulatory proteins in cancer. This position requires the expertise in cell biology and molecular biology techniques, including PCR, qRT-PCR, Western Blotting, co-Immunoprecipitation, ChIP, ChIPSeq, flow cytometry, CRISPR-based “epigenome editing”. Prior work experience with animals such as transgenic mice and xenograft models of cancer would be a plus. Successful candidate will be a part of an interdisciplinary team focused on development and pre-clinical evaluation of novel anti-cancer drug candidates.
Successful candidate will be co-mentored by Drs Cierpicki and Ryan. We offer highly interdisciplinary training in cancer epigenetics that will cover stat-of-the art epigenomic techniques combined with modern tools in chemical biology and drug discovery (e.g. protein-protein interaction inhibitors and PROTACs).

Requirements:
Applicant must have PhD in biology or related field. The candidates must be a first author on at least 2-3 publications. This position requires extensive experience in cell and molecular biology techniques. Furthermore, excellent oral and written communication skills in English are required as well as the ability to conduct independent scientific investigations.

How to apply
Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to:
tomaszc@umich.edu or rjhryan@med.umich.edu.

Contact: Tomasz Cierpicki, PhD, Associate Professor
Department of Pathology, University of Michigan
Ann Arbor, MI, 48109, USA
https://www.pathology.med.umich.edu/index.php?t=page&id=1473
e-mail: tomaszc@umich.edu

Relevant publications
1. Klossowski S, et al. Cierpicki T, Grembecka J. (2019) Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. J Clin Invest. 130(2):981-997
2. Ryan RJH, et al: A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell reports. 2017; 21(3):784-797
3. Huang H. et al, Cierpicki T. Covalent Inhibition of NSD1 histone methyltransferase. Nature Chem. Biol. 2020,; 31. doi: 10.1038/s41589-020-0626-6.




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Job posting number:#7070436
Application Deadline:Open Until Filled
Employer Location:University of Michigan
Ann Arbor,Michigan
United States
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